Article 14120

Title of the article

RHEOLOGICAL PARAMETERS OF SERUM AND PLASMA OF BLOOD IN PATIENTS OPERATED ON HEART IN THE CONDITIONS OF ARTIFICIAL BLOOD CIRCULATION DURING THE PER- AND INTRAOPERATIVE PERIOD 

Authors

Moiseeva Inessa Yakovlevna, Doctor of medical sciences, professor, head of the sub-department of general and clinical pharmacology, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: moiseeva_pharm@mail.ru
Potapov Vladimir Vladimirovich, Postgraduate student, Donetsk National Medical University named after M. Gorky (16, Ilyicha avenue, Donetsk, Ukraine), E-mail: x3x3x23@rambler.ru
Zenin Oleg Konstantinovich, Doctor of medical sciences, professor, sub-department of human anatomy, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: zen.olegz@gmail.com
Kuznetsova Irina Vadimovna, Doctor of medical sciences, professor, sub-department of anesthesiology, intencive care and emergency medicine, Donetsk National Medical University named after M. Gorky (16, Ilyicha avenue, Donetsk, Ukraine), E-mail: reanim@dsmu.edu.ua
Dmitriev Leonid Sergeevich, Postgraduate student, Central Research Laboratory, Donetsk National Medical University named after M. Gorky (16 Ilyicha, avenue, Donetsk, Ukraine), E-mail: x3x3x23@rambler.ru 

Index UDK

[612.014.462.7+612.014.462.8]:611.018.54+616.12-009.72 

DOI

10.21685/2072-3032-2020-1-14 

Abstract

Background. Set the values of surface tension and dilatational viscoelasticity: 1) serum and plasma in patients operated on for the heart under cardiopulmonary bypass, in the peri-and intraoperative periods; 2) blood serum during cardiopulmonary bypass.
Materials and methods. In 70 patients with ischemic heart disease, the average age 62,1±0,9, operated on under cardiopulmonary bypass for coronary heart disease and acquired valvular heart disease, the prospective study of surface tension and dilatation viscoelasticity of blood serum and plasma was performed. There were used the methods of drop and bubble form (Tensiometers PAT-1 and РАТ-2P SINTERFACE Technologies, Berlin, Germany).The blood for research was sampled an hour before operation, in the 5th minute of cardiopulmonary bypass, after 12 hours (1-st day) and in 7 days after operation. The rheological active markers (glucose, protein, albumen, urea and creatinine) were choose from routine biochemical parameters to evaluate.
Results. On the 1st day after surgery, there was a statistically significant increase in glucose, urea and creatinine levels and a statistically significant decrease in total protein and albumin. Against this background, the nature of the changes in surface tension and viscoelastic modulus indicated a significant increase in serum surfactants. By the 7th day of the postoperative period, positive dynamics of the studied biochemical parameters was noted. Of the rheological indicators, an increase in the module at a frequency of 0.01 Hz can be noted with a simultaneous decrease in the phase angle. This indicates an increase in surface elasticity with a practically constant surface viscosity. Noteworthy are close to zero coefficients of the dependence of dilatational viscosity on the oscillation frequency. At the same time, the group of patients during cardiopulmonary bypass reliably stands out among other groups of patients in terms of the size bviscosity. This indicates a change in the mechanism of formation of dilatational viscosity, probably due to the introduction of large volumes of infusion media into the vascular bed in a short time.
Conclusion. Pathological changes in biochemical markers which influence blood viscosity (glucose, protein, albumen, urea and creatinine) were accompanied by significant changes in surface tension and dilatation viscoelasticity of serum and plasma blood. The same time these biochemical markers are not the dominant predictors of the changes in blood rheology and viscosity. 

Key words

surface tension, blood rheology, coronary heart disease, valvular heart disease 

Download PDF
References

1. Litvitskiy P. F. Patofiziologiya: v 2 t. [Pathophysiology: in 2 volumes]. Moscow: GEOTAR–Media, 2014, vol. 2, 794 p. [In Russian]
2. Chernyakhovskaya N. E. Korrektsiya mikrotsirkulyatsii v klinicheskoy praktike [Correction of microcirculation in clinical practice]. Moscow: Binom, 2013, 208 p. [In Russian]
3. Kazakov V. N., Knyazevich V. M., Sinyachenko O. V., Fainerman V. B., Miller R. Progress in Colloid and Interface Science. Leiden: Brill Publ, 2009, vol. 1, pp. 519–566.
4. Krishnan A., Wilson A., Sturgeon J., Siedlecki A. Biomaterials. 2005, vol. 26, pp. 3445–3453.
5. Kazakov V. N., Sinyachenko O. V., Fainerman V. B., Pison U., Miller R. Dynamic surface tensiometry in medicine. Amsterdam: Elsevier, 2000, 373 p.
6. Kazakov V. N., Barkalova E. L., Levchenko L. A., Klimenko T. M., Fainerman V. B., Miller R. Colloids Surfaces A. 2011, vol. 391, pp. 190–194.
7. Chevalier G., Stephen T., James L. The journal of alternative and complementary medicine. 2013, vol. 19, no. 2, pp. 102–110.
8. Shishehbor M. H., Venkatachalam S., Sun Z. J Am CollCardiol. 2013, vol. 62 (21), pp. 1948–1956.
9. Dormandy J. A. Biomed. Eng. 1974, vol. 9, no. 27, pp. 284–291.
10. Kazakov V. N., Fainerman V. B., Kondratenko P. G., Elin A. F., Sinyachenko O. V., Miller R. Colloids Surfaces B. 2008, vol. 62, pp. 77–82.
11. Fainerman V. B., Trukhin D. V., Zinkovych I. I., Miller R. Adv. Colloid Interface Sci. 2018, vol. 255, pp. 34–46.
12. Zholob S. A., Makievski A. V., Miller R., Fainerman V. B. Progress in Colloid and Interface Science. Leiden: Brill Publ, 2011, vol. 2, pp. 39–60.
13. Zholob S. A., Makievski A. V., Miller R., Fainerman V. B. Adv. Colloid Interface Sci. 2007, vol. 134–135, pp. 322–329.
14. Lucassen J., van den Tempel M. Chem. Eng. Sci. 1972, vol. 27, pp. 1283–1291.
15. Lyakh Yu. E., Gur'yanov V. G., Khomenko V. N., Panchenko O. A.Osnovy komp'yuternoy biostatistiki: analiz informatsii v biologii, meditsine i farmatsii statisticheskim paketom MedStat [Basics of computer biostatistics: analysis of information in biology, medicine and pharmacy with the statistical package MedStat]. Donetsk: Papakitsa E.K., 2006, 214 p. [In Russian]

 

Дата создания: 20.05.2020 12:52
Дата обновления: 20.05.2020 15:41